![]() ![]() Although a number of surgical procedures have been used to restore motor function following PNIs, the currently available nerve repair surgeries result in poor functional recovery due primarily to insufficient axonal regeneration and a failure to reinnervate the denervated motor endplates (MEPs) in the target muscle. Peripheral nerve injuries (PNIs) to the extremities and resultant muscle paralysis are a major source of chronic disabilities which limit the opportunities to work and diminish quality of life. Specifically, the denervated TA caused by peroneal nerve injuries can be reinnervated with a NMEG from the GM-l. NMEG-NMZ surgery is feasible for limb reinnervation. The NMEG-NMZ pilot study showed that this technique resulted in optimal muscle force recovery. The locations of MEP bands in the GM and TA muscles and nerve supply patterns demonstrated that an NMEG pedicle can be harvested from the GM-l and implanted into the NMZ within the TA muscle. The GM was composed of two neuromuscular compartments, lateral (GM-l) and medial (GM-m), each of which was innervated by a separate nerve branch derived from the tibial nerve and had a vertically positioned MEP band. A single MEP band was located obliquely in the middle of the TA. The results showed that the TA was innervated by the deep peroneal nerve. At the end of a 3-month recovery period, maximal muscle force was measured to document functional recovery. The denervated TA was reinnervated by transferring an NMEG pedicle from the ipsilateral lateral GM. Five adult rats underwent TA nerve transaction. As the NMEG-NMZ technique involves in nerves and motor endplates (MEPs), the nerve supply patterns and locations of the MEP bands within the gastrocnemius (GM) and TA muscles of rats were investigated using Sihler’s stain and whole-mount acetylcholinesterase (AChE) staining, respectively. The aim of this study was to explore anatomical feasibility of limb reinnervation with our recently developed nerve-muscle-endplate grafting (NMEG) in the native motor zone (NMZ). As current treatment methods result in poor functional recovery, novel treatment approaches need to be studied. TA paralysis could cause “foot drop,” a disabling condition that can make walking difficult. ![]() Peroneal nerve injuries results in tibialis anterior (TA) muscle paralysis. ![]()
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